解剖学和形态学
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行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
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综合和补充性医学
医学伦理学
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医学,全科和内科
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心理学,临床
abstract::Sprague-Dawley rats were treated with N-nitrosomorpholine (NNM) alone (7 weeks, 120 mg/l in drinking water), with NNM followed by phenobarbital (PB) (750 mg/l for 6 weeks) or PB alone. The livers from these animals were investigated for glycogen content and activities of glucose-6-phosphatase, glucose-6-phosphate dehy...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.7.931
更新日期:1983-01-01 00:00:00
abstract::The anti-neoplastic agent procarbazine is genetically active in a variety of short term mutagenicity tests, and it also possesses carcinogenic and teratogenic potential. This compound has consistently yielded false negative results in in vitro microbial mutagenicity tests in the presence and absence of mammalian metab...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.3.347
更新日期:1983-01-01 00:00:00
abstract::To study the relationship between epidermal DNA synthesis and carcinogenesis, hairless mice of both sexes were given a single topical application of 1 mg N-methyl-N-nitrosourea (MNU) in acetone. A control group received only MNU, whereas other groups were injected i.p. with 5 mg hydroxyurea (HU), 1 h, 45 min and 15 mi...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/3.8.891
更新日期:1982-01-01 00:00:00
abstract::Two samples of 4-amino-2-nitrophenol were tested for mutagenicity in Salmonella typhimurium strains TA1535, TA1537, TA1538, TA98, and TA100. Significant mutagenic activity was detected with a sample of this compound obtained from Aldrich (technical grade (Aldrich), TGA) both in the presence and in the absence of a rat...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/3.7.809
更新日期:1982-01-01 00:00:00
abstract::The sensitivity of various mouse strains to skin carcinogenesis has been investigated in two ways; (i) by comparing carcinogenesis induced by treatments involving both the application of tumour promoters and the application of single or multiple doses of a carcinogen, and (ii) by comparing the binding characteristics ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/3.7.805
更新日期:1982-01-01 00:00:00
abstract::The Manchester (England) Children's Tumour Registry is population-based with a high level of ascertainment. Pathologic review ensured diagnostic accuracy. Routine monitoring of annual incidence revealed a significant increase in germ cell tumours from approximately 1 per million person years to approximately 4. Analys...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/3.1.75
更新日期:1982-01-01 00:00:00
abstract::Comparative in vitro metabolic experiments with 7,8-benzoflavone using microsomes prepared from the livers of control Sprague-Dawley rats or from rats of the same strain treated with phenobarbitone, 3-methylcholanthrene, or Aroclor 1254 (known inducers of hepatic cytochrome P450 mixed function oxidases) disclose varia...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/3.2.229
更新日期:1982-01-01 00:00:00
abstract::Autoradiography has been used to study the effect of 12-O-tetradecanoylphorbol-13-acetate (TPA), 4-O-methyl TPA, and phorbol on metabolic cooperation between human diploid fibroblasts. When the donors, hypoxanthine-guanine phosphoribosyl transferase+ (HGPRT+) cells, and recipients, HGPRT- cells, were plated together i...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/3.10.1207
更新日期:1982-01-01 00:00:00
abstract::DNA repair after gamma radiation was studied in purified T lymphocytes from young and aged subjects. Two different assays were employed. In the first, T lymphocytes were stimulated with phytohemagglutinin (PHA) for 72 h and then treated with hydroxyurea, irradiated with 30 K rads and pulsed with [3H]thymidine (TdR) fo...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/3.1.45
更新日期:1982-01-01 00:00:00
abstract::The metabolism of 7,12-dimethylbenz[a]anthracene (DMBA), benzo[a]pyrene (BP) and benz[a]anthracene (BA) by epithelial cell aggregates and fibroblasts in culture has been investigated using mammary tissue obtained from female Wistar rats. The results show that: (a) both types of mammary cells metabolise all three hydro...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/3.2.203
更新日期:1982-01-01 00:00:00
abstract::Male Leeds strain rats were given a diet containing either 0.06% 3'-methyl-4-dimethylaminoazobenzene (3'-MeDAB) or 0.05% 2-acetylaminofluorene (2-AAF), alone or together with 0.0067% 3-methylcholanthrene (MeCh). MeCh both reduced the incidence of hepatic neoplasms induced by 3'-MeDAB and delayed their development. Wit...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/3.9.981
更新日期:1982-01-01 00:00:00
abstract::Measurements were made of the effects of phenolic compounds, some of which are present in the human diet, on the nitrosation of proline by nitrite to give N-nitrosoproline (NPRO). In vitro, resorcinol, catechin, p-nitrosophenol and phenol were catalysts and chlorogenic acid an inhibitor; guaiacol showed a marginal cat...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/3.9.1045
更新日期:1982-01-01 00:00:00
abstract::A line of C3H mouse fibroblasts designated CVP3SC6 (CVP) was found to be nonresponsive to the induction of morphological transformation by the polycyclic aromatic hydrocarbon benzo[a]pyrene (BaP) and its BaP-7,8-diol and BaP-diol-epoxide derivates. This cell line was, however, susceptible to BaP-induced mutation to ou...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/3.9.963
更新日期:1982-01-01 00:00:00
abstract::The rate of formation of N-hydroxy-N-methyl-4-aminoazobenzene (N-OH-MAB) derivatives from N,N-dimethyl-4-aminoazobenzene (DAB) derivatives and from N-methyl-4-aminoazobenzene (MAB) derivatives was measured by the e.s.r. spectroscopy, and the rate of N-demethylation of DAB derivatives was measured by h.p.l.c. The rate ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/3.12.1393
更新日期:1982-01-01 00:00:00
abstract::The localization of benzo[a]pyrene-deoxyguanosine adducts was studied by indirect immunofluorescence in cultured BALB/c epidermal cells exposed to (+/-) 7 alpha, 8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (the anti-isomer) utilizing an antiserum specific for the major benzo[a]pyrene-de...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/3.3.345
更新日期:1982-01-01 00:00:00
abstract::Purified DNA was modified in vitro by 3H-labelled O-acetyl or O,O'-diacetyl-4-hydroxyaminoquinoline-1-oxide (Ac4HAQO or di Ac-4HAQO). It was then subjected to the action of the single-stranded DNA specific nuclease S1 and the digested fractions were analysed. For both types of modified DNA, the release of non-modified...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/3.4.435
更新日期:1982-01-01 00:00:00
abstract::Disulfiram (DSF) can considerably alter the organotropy of chemical carcinogens. For N-nitrosodimethylamine and for N-nitrosodiethylamine the organotropy is shifted from the liver to the nasal cavity or the oesophagus, respectively. Whereas the influence of DSF or its metabolites on enzyme systems has been studied, li...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/3.5.563
更新日期:1982-01-01 00:00:00
abstract::3-Methylcholanthrene (3-MC) pretreatment induces the liver microsomal 2-acetylaminofluorene (2-AAF) N-hydroxylase activity of C57BL6 responsive mice. The same pretreatment modifies this enzyme by significantly increasing its apparent Km value which, moreover, becomes protein concentration dependent. After 3-MC inducti...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/3.11.1325
更新日期:1982-01-01 00:00:00
abstract::A number of model systems have been developed to study the initiating and promoting phases of neoplastic development in rats liver. Four of these protocols use diethylnitrosamine (DEN) initiation, but employ different methods of promotion. The present studies were designed to evaluate these systems under standardized ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/3.8.851
更新日期:1982-01-01 00:00:00
abstract::A series of experiments was conducted to determine the efficacy of 15 synthetic retinoic acid amides (retinamides) as inhibitors of chemical carcinogenesis of the urinary bladder in C57BL/6 x DBA/2F1 mice. Eight of the retinamides tested had significant protective activity when administered at nontoxic levels in the d...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/3.12.1469
更新日期:1982-01-01 00:00:00
abstract::The activity levels of L-ornithine carboxy-lyase (ODC) (E.C. 4.1.1.17) and S-adenosyl-L-methionine carboxy-lyase (SAM-D) (E.C.4.1.1.50) were determined in individual papillomas induced in mouse skin by a two-stage technique, and in normal mouse epidermis. Cycloheximide treatment abolished both enzyme activities. In no...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/3.3.303
更新日期:1982-01-01 00:00:00
abstract::The reaction of chloroacetaldehyde, a reactive metabolic of the carcinogen vinyl chloride, with DNA produces in addition to the hitherto known adducts, 1,N6-ethenoadenine and 3,N4-ethenocytosine, an ethenoguanine adduct, namely N2,3-ethenoguanine. This adduct is formed in the reaction of chloroacetaldehyde with the fr...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/3.6.663
更新日期:1982-01-01 00:00:00
abstract::3-Methyladenine is one of the major products formed by reaction of a large number of environmental methylating agents with DNA in vivo and in vitro. In spite of the rapid spontaneous depurination of this base an enzyme, 3-methyladenine DNA glycosylase, has been shown to catalyse its excision. The relevance of this enz...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/3.7.747
更新日期:1982-01-01 00:00:00
abstract::gamma-Glutamyl transpeptidase (gamma GT) positive hepatocytes were isolated from F344 male rats fed 2-acetylaminofluorene. The isolation procedure is rapid and highly selective for cells exhibiting gamma GT on their surface. Suspensions of liver cells obtained from perfusion in situ with a collagenase solution were in...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/3.11.1349
更新日期:1982-01-01 00:00:00
abstract::Benzo(a]pyrene was metabolized in liver cell lines derived from BC-IV and BD-IV rats which included several chemically-transformed lines (IAR-6-1; IAR-19; IAR-28), one spontaneous transformant (IAR-27) as well as one non-malignant line (IAR-20). Cultures were treated with tritiated benzo[a]pyrene over a 5-day period. ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/3.6.635
更新日期:1982-01-01 00:00:00
abstract::Strains of laboratory mice vary markedly in their susceptibility to two-stage skin carcinogenesis using 7,12-dimethylbenz[a]anthracene (DMBA) as the initiating carcinogen and croton oil as promoter. This study has been undertaken in order to clarify the basis of the strain differences. LACA mice were used as the susce...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/3.1.99
更新日期:1982-01-01 00:00:00
abstract::An electron microscope study was carried out on changes in the pancreatic acinar tissues of male Syrian hamsters during the course of induction of pancreatic neoplasia by lifetime weekly injections of N-nitroso-bis(2-hydroxypropyl)amine (BHP). The dominant process observed was a loss of differentiation of the acinar c...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/3.5.485
更新日期:1982-01-01 00:00:00
abstract::To study the roles of DNA polymerases alpha and beta during replication and repair of damaged DNA, use was made of the fact that during chronic treatment with carcinogens, replication and repair do not necessarily follow the same time sequence. Early cell damage and restorative hyperplasia cause a transient wave of DN...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/2.1.61
更新日期:1981-01-01 00:00:00
abstract::The reaction of deoxyadenosine with beta-propiolactone produces two derivatives. One is 1-(2-carboxyethyl)-2'-deoxyadenosine (CEdA) first described by Maté, et al. The proposed structure for the other is 3-(beta-D-2-deoxyribosyl)-7,8-dihydropyrimido-[2,l-i]purine-9-one (dDPP). Spectral characteristics of both compound...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/2.2.73
更新日期:1981-01-01 00:00:00
abstract::Dose-response relationships in the induction of urinary bladder cancer in male C57BL/6 x DBA/2-F1 (BDF) mice by intragastric instillation of N-butyl-N-(4-hydroxybutyl)nitrosamine (OH-BBN) were studied. Administration of a total dose of 0 to 80 mg OH-BBN in 10 weekly fractions to groups of 25 mice resulted in a linear ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/2.3.251
更新日期:1981-01-01 00:00:00
abstract::An intrasanguineous host-mediated assay was used to establish the mutagenic potential of a series of dialkylnitrosamines to E. coli K12/343/113 in the liver and spleen of mice. For calibrating purposes, dose- and time-dependent kinetics of mutation induction by the model compound diethylnitrosamine in this assay was d...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/2.9.909
更新日期:1981-01-01 00:00:00
abstract::Inbred male Leeds rats were administered either the liver carcinogen N-nitrosopiperidine or the non-carcinogen 2,2',6,6'-tetramethyl-N-nitrosopiperidine in their drinking water at a concentration of 0.02%. Treatment was continued until the animals were killed, at 12 or 28 days, when their hepatic tissues were removed ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/2.5.385
更新日期:1981-01-01 00:00:00
abstract::The urinary excretion of dimethylnitrosamine (DMN) was studied in male Sprague-Dawley rats. Animals were given DMN (3, 5, 10, 20, 30 and 50 mg/kg body weight, i.p.) or [3H]DMN (0.1, 1 and 3 mg; 8.7, 1.5 and 0.28 mCi/kg body weight, respectively, i.p.) diluted with sterile 0.9% NaCl. Urine was collected for 24 h after ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/2.7.609
更新日期:1981-01-01 00:00:00
abstract::The polypeptide hormone epidermal growth factor (EGF) has been shown to enhance adenovirus type 5 transformation of a cloned culture of rat embryo cells (CREF) and X-ray or u.v.-light induced transformation of 10T1/2 mouse embryo cells. In both systems, the degree of enhancement was quantitatively similar to that obse...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/2.3.183
更新日期:1981-01-01 00:00:00
abstract::Cultured human epidermal cells which require no feeder layer were used to study metabolism of benzo[a]pyrene (BP) and DNA adduct formation. The cultures were prepared from a single cell suspension and maintained at a pH of 5.9--6.2. At 2 microM BP some cell toxicity was observed, and substantial cell death occurred at...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/2.7.581
更新日期:1981-01-01 00:00:00
abstract::The addition of supplementary cytosolic fraction greatly enhances the activation of 2-acetylaminofluorene (AAF) by uninduced 9,000 x g supernatant fractions (S9) in the Ames test. Uninduced S9 is poor at activating AAF in the Ames test (although it is effective in the liquid based fluctuation test) probably because cy...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/2.11.1081
更新日期:1981-01-01 00:00:00
abstract::Hairless mice were given 5 topical applications of 470 nmol 20-methylcholanthrene (MCA) at one week intervals. In one experimental group the MCA was dissolved in reagent grade acetone alone, in another group it was dissolved in a mixture consisting of 50% acetone and 50% dimethyl sulfoxide (DMSO). A control group rece...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/2.11.1129
更新日期:1981-01-01 00:00:00
abstract::A single i.p. injection of diethylnitrosamine (DEN) or benzo[a]pyrene (BAP) in 1-day-old female rats produced a high incidence of gamma-glutamyltranspeptidase-(GGT)-positive hepatocyte foci within 4 weeks after the rats were weaned onto a 0.05% phenobarbital diet; the injection of benzo[e]pyrene did not produce foci u...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/2.5.463
更新日期:1981-01-01 00:00:00
abstract::Male rats were treated with [ring-3H]N-acetyl-2-aminofluorene and sacrificed at different periods of time after a single i.p. dose. Chromatin was isolated from liver homogenates and treated with RNAse and proteinase K. The resulting crude DNA was purified as the N-hexadecyl-N-trimethylammonium salt. The amounts of 2-a...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/2.8.737
更新日期:1981-01-01 00:00:00
abstract::One hundred forty-seven female Sprague-Dawley rats were divided into 5 groups and at 60 days of age were treated i.g. with 5 mg of 7,12-dimethylbenzanthracene (DMBA) suspended in 1.0 ml of sesame oil. Selenium (Se), as selenium dioxide (SeO2), was administered in the drinking water to 4 of the 5 groups (30 rats/group)...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/2.6.519
更新日期:1981-01-01 00:00:00